منابع مشابه
Renal Proximal Tubular Albumin Reabsorption: Daily Prevention of Albuminuria.
Although the glomerular filtration coefficient of albumin is small, the daily filtered load can be as much as 8 g. To prevent such massive losses of albumin, quantitative reabsorption along the proximal tubules is accomplished by "receptor"-mediated endocytosis. Albumin reaches the lysosomes where it is degraded to amino acids.
متن کاملObesity‐associated glomerular inflammation increases albuminuria without renal histological changes
1 Department of Nephrology, Kindai University Faculty of Medicine, Kindai University Nara Hospital, Nara, Japan 2 Department of Food Science and Nutrition, Faculty of Agriculture, Kindai University, Nara, Japan 3 Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA 4 Department of Applied Biological Chemistry, Graduate School of Agriculture, Kindai University, Nara...
متن کاملInhibition of the Metabolic Degradation of Filtered Albumin Is a Major Determinant of Albuminuria
Inhibition of the degradation of filtered albumin has been proposed as a widespread, benign form of albuminuria. There have however been recent reports that radiolabeled albumin fragments in urine are not exclusively generated by the kidney and that in albuminuric states albumin fragment excretion is not inhibited. In order to resolve this controversy we have examined the fate of various radiol...
متن کاملImpaired Albumin Uptake and Processing Promote Albuminuria in OVE26 Diabetic Mice
The importance of proximal tubules dysfunction to diabetic albuminuria is uncertain. OVE26 mice have the most severe albuminuria of all diabetic mouse models but it is not known if impaired tubule uptake and processing are contributing factors. In the current study fluorescent albumin was used to follow the fate of albumin in OVE26 and normal mice. Compared to normal urine, OVE26 urine containe...
متن کاملα1-Microglobulin/albumin ratio may improve interpretation of albuminuria in statin-treated patients.
BACKGROUND Statins can cause tubular proteinuria by inhibiting tubular reabsorption of urinary proteins. To distinguish between microalbuminuria originating from glomerular leakage of albumin and tubular microalbuminuria due to statin therapy, the α1-microglobulin/albumin ratio is evaluated in patients taking statins and compared to untreated patients. METHODS Ten apparently healthy subjects ...
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ژورنال
عنوان ژورنال: Journal of the American Medical Association
سال: 1887
ISSN: 0002-9955
DOI: 10.1001/jama.1887.02391480026010